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Table 1 Clinical and demographical features of three patients

From: Case series of intravenous thrombolysis for acute ischemic stroke in confirmed COVID-19 patients: single-centre experience

  Patient 1 Patient 2 Patient 3
Age 62 59 58
Sex Male Female Female
Patient history
 Pre-stroke mRS (0–5) 0 0 0
 Comorbidities Hypertension, prediabetic Hypertension, Diabetic, Obesity Hypertension, Obesity
 Antiplatelet/anticoagulant No No No
COVID-19 characteristics
 Nasopharyngeal swab Positive Positive Positive
 Chest X-ray Viral pneumonia characteristics (bilateral) Viral pneumonia characteristics (bilateral) Viral pneumonia characteristics (bilateral)
 Fever No Yes No
 Cough Yes No No
 Dyspnea No Yes Yes
 Myalgia No No No
 Gastrointestinal symptoms No No No
 Pharmacological treatment Favipiravir, antibiotic therapy; Levofloxasin, Azithromycin and enoxoparin 40 mg once daily Favipiravir, antibiotic therapy; Levofloxasin, Ceftriaxone and enoxoparin 40 mg once daily Favipiravir, antibiotic therapy; Levofloxasin, Ceftriaxone. Enoxoparin (-)
 IV tPA Yes (80% of the total IV tPA dose) Yes Yes (80% of the total IV tPA dose)
 Initial SpO2 (room air) 90% 80% 93%
 Oxygen therapy Nasal Cannule NRB NRB
Laboratory findings
 Haemaglobin, g/dl 15.4 11 13.8
 Leucocyte × 109/L 7.7 10.2↑ 11.8↑
 Platelets × 109/L 538↑ 516↑ 314
 Neutrophils, % 71↑ 89↑ 78↑
 Lymphocytes, % 12↓ 6↓ 15↓
 aPTT, s 26 27 28.1
 PT, s 13.4 13.8 13.4
 INR 0.94 0.97 0.92
 Fibrinogen, mg/dl 473↑ 655↑ 423↑
 D-dimer, ng/ml 1710↑ > 20,000↑ 910↑
 AST, U/L 31 13 15
 ALT, U/L 58↑ 18 9
 Creatinine, mg/dl 0,4 0.8
 Glucose, mg/dl 168↑ 410↑ 140
 LDH, U/L 813↑
 CRP, mg/dl 0.7 8.3↑ 2.9↑
Stroke features
 Clinical symptoms Right hemiparesis, aphasia Left hemiparesis, dysarthria Right hemiparesis,dysarthria
 NIHSS at baseline 12 10 10
 NIHSS after 24 h 4 6 Not available
 Haemorrhagic transformation No No Yes (Intraventricular haemorrhagic)
 Complication None Respiratory insufficiency (ARDS) Respiratory insufficiency (ARDS)
 Outcome Clinical recovery Death Death
  1. ALT alanine aminotransferase, aPTT activated partial thromboplastin time, ARDS acute respiratory distress syndrome, AST aspartate aminotransferase, COVID-19coronavirus disease 2019, CRP C-reactive protein, IV tPA intravenous tissue plasminogen activator, INR international normalized ratio, LDH lactate dehydrogenase, mRS modified ranking scale, NIHSS National Institutes of Health Stroke Scale, spo2oxygen saturation, PT prothrombin time