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Table 3 Comparisons of categorical data between migraine cases according to MRI findings

From: Migraine in patients with rheumatoid arthritis and its relation to disease activity

Qualitative data

Normal brain MRI

Abnormal brain MRI

χ2

P value

N (%)

28 (45.2%)

34 (54.8%)

Sex

  

FET

0.450

 Male

5 (17.9%)

3 (8.8%)

  

 Female

23 (82.1%)

31 (91.2%)

  

Current smoking

3 (10.7%)

6 (17.6%)

FET

0.494

Positive RF

20 (71.4%)

23 (67.6%)

0.103

0.748

Positive anti-CCP

23 (82.1%)

31 (91.2%)

FET

0.450

Rheumatoid Disease Activity

  

FET

0.393

 Remission (DAS28 < 2.6)

3 (10.7%)

3 (8.8%)

  

 Low (DAS28 ≥ 2.6 to ≤ 3.2)

10 (35.7%)

7 (20.6%)

  

 Moderate (DAS28 > 3.2 to ≤ 5.1)

15 (53.6%)

22 (64.7%)

  

 High (DAS28 > 5.1)

0 (0%)

2 (5.9%)

  

Functional losses (MHAQ)

  

0.754

0.686

 Mild (MHAQ < 1.3)

11 (39.3%)

10 (29.4%)

  

 Moderate (MHAQ 1.3 to 1.8)

10 (35.7%)

13 (38.2%)

  

 Severe (MHAQ > 1.8)

7 (25%)

11 (32.4%)

  

Fibromyalgia

6 (21.4%)

8 (23.5%)

0.039

0.844

Sjogren's syndrome

3 (10.7%)

4 (11.8%)

FET

1.000

NSAIDs use

0 (0%)

5 (14.7%)

FET

0.058

Corticosteroid use

6 (21.4%)

3 (8.8%)

FET

0.277

Methotrexate use

18 (64.3%)

20 (58.8%)

0.193

0.660

Sulfasalazine use

2 (7.1%)

3 (8.8%)

FET

1.000

Leflunomide use

1 (3.6%)

2 (5.9%)

FET

1.000

Anti-TNF-α use

0 (0%)

3 (8.8%)

FET

0.245

Hydroxychloroquine use

13 (46.4%)

16 (47.1%)

0.002

0.961

 Migraine type

  

FET

1.000

 Episodic

25 (89.3%)

30 (88.2%)

  

 Chronic

3 (10.7%)

4 (11.8%)

  

Migraine with aura

5 (17.9%)

14 (41.2%)

3.929

0.047

Numerical Rating Scale

  

FET

0.445

 Mild

7 (25%)

4 (11.8%)

  

 Moderate

9 (32.1%)

12 (35.3%)

  

 Severe

12 (42.9%)

18 (52.9%)

  
  1. Bod values indicate P value is significant (less than 0.05)
  2. Data are N%), test of significance is Chi-square test or Fisher’s exact test (FET). p value significant < 0.05. Quantitative data are median (25th percentile–75th percentile), test of significance is Mann–Whitney U-test. MRI, magnetic resonance imaging; RF, rheumatoid factor; Anti-CCP, anti-citrullinated peptide; DAS, Disease Activity Score; MHAQ, Modified Health Assessment Questionnaire; NSAID, non-steroidal anti-inflammatory drug; TNF-α, tumor necrosis factor-alpha; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein