Table 1 Demographic and clinical characteristics of the 20 NMOSD patients with APS compared to NMOSD patients without APS
|  | NMOSD patients with APS (n = 20) | NMOSD patients without APS (n = 70) | p value |
|---|---|---|---|
Age at onset in years (mean ± SD) (Range) | 30 ± 11.3 (11–50) | 31.2 ± 12.0 (6–56) | 0.440 |
Sex (n, %) | Â | Â | Â |
 Female | 16 (80%) | 52 (73.9%) | 0.771 |
 Male | 4 (20%) | 18 (26.1) | |
Seroprevalence of Anti-Aquaporin 4 (n, %) | |||
 Aquaporin 4-seropositive | 17 (85%) | 60 (85.7%) | 1.000 |
 Aquaporin 4-seronegative | 3 (15%) | 10 (14.3%) | |
Other core symptoms along the disease course (n, %) | |||
 Acute myelitis | 20 (100%) | 51 (72.9%) | 0.005 |
 Optic neuritis | 13 (65%) | 54 (77.1%) | 0.603 |
 Acute brain stem syndrome | 11 (55%) | 20 (28.6%) | 0.028 |
 Acute diencephalic syndrome | 3 (15%) | 3 (4.3%) | 0.121 |
 Acute cerebral syndrome | 5 (25%) | 26 (37.1%) | 0.314 |