Skip to main content

Table 2 Characteristics of included systematic reviews regarding stroke in COVID-19 infection

From: Neurological manifestations of COVID-19 infection: an umbrella review

Authors Origin Type Quality Number of included studies Types of included studies Assessing the quality of included studies Searched databases Main results
1. Valencia-Enciso et al. 2020 [42] Colombia Systematic review Moderate 47 Cohort, case series, case report, case–control NOS Pubmed, Scopus A positive correlation seemed to exist between COVID-19 severity and temporality of stroke
2. Fraiman et al. 2020 [43] South Korea Systematic review Critically Low 80 Not mentioned None Pubmed Cerebrovascular events, especially ischemic stroke, were a common neurological manifestation in COVID-19 patients
3. Lee et al. 2020 [32] Malaysia Systematic review + meta-analysis Moderate 28 Cohort, case series, case report STROBE2 Pubmed, Medline, Cinhal Stroke is an uncommon symptom in COVID-19 patients, but can be prognostic factor and an indicator of the severity of the infection
4. Bhatia et al. 2020 [44] India Systematic review Moderate 30 Cohort, case series, case report Oxford CEBM3 critical appraisal tool Pubmed, Embase, Scopus COVID-19 is associated with higher mortality rates in stroke patients
5. Wijeratne et al. 2020 [40] Australia Systematic review Low 18 Cohort, case series, case report, case–control, reviews None Pubmed, Embase, Cochrane Library, Medline, Cinhal, Ovid Neutrophil–Lymphocyte ratio at time admission is associated with the duration before onset of clinical features of AIS3
6. Fridman et al. 2020 [33] Canada Systematic review + meta-analysis Low 10 Not mentioned None Pubmed, medRxiv, bioRxiv, Research Square search engines The mortality of Stroke in COVID-19 patients is associated with age, comorbidities and the severity of the infection
7. Yamakawa et al. 2020 [35] USA Systematic review + meta-analysis Moderate 26 Cohort, case series, case report, case–control Assessment of risk of bias in prevalence studies Pubmed, Embase, The frequency of detected stroke in hospitalized patients was associated with age and other stroke risk factors
8. Katsanos et al. [34] Greece Systematic review + meta-analysis High 18 Cohort NOS Pubmed, Scopus COVID-19 infection is associated with an increased risk of ischemic stroke, especially cryptogenic stroke; in addition to an increased risk of mortality
9. Tan et al. 2020 [37] Singapore Systematic review + meta-analysis Moderate 39 Cohort, case series, case report NOS, JBI5 tool Pubmed, Embase AIS is associated with COVID-19 infection with a high mortality rate
10. Nannoni et al. 2020 [36] UK Systematic review + meta-analysis Moderate 61 Cohort, case series, case report, case–control, letters NOS Pubmed, Scopus, MedRxiv Acute cerebrovascular events are associated with the severity of the disease and pre-existing vascular risk factors in COVID-19 patients
11. Fatima et al. 2020 [41] USA Systematic review Moderate 6 Cohort, case series, case report GRADE6, Cochrane Collaboration’s tool Pubmed, Embase, Scopus, Google Scholar, Cochrane Library, Medline Stroke is associated with COVID-19 infection in patients with underlying risk factors including hypertension
12. Siepmann et al. 2021 [38] Germany Cohort + Systematic review Critically Low 2 Cohort, experimental Oxford CEBM tool Pubmed, Embase, Cochrane Library The severity of COVID-19 infection is associated with an increased risk of acute stroke
13. Szegedi et al. 2020 [39] Germany Narrative review + Systematic review Critically Low 25 Cohort, case series, case report None Pubmed, Scopus In COVID-19 patients the most common type of stroke was AIS
  1. 1. NOS :Newcastle–Ottawa Scale, 2. STROBE: Strengthening the Reporting of Observational Studies in Epidemiology, 3. CEBM: Centre for Evidence-Based Medicine, 4. AIS: Acute Ischemic Stroke, 5. JBI: Joanna Briggs Institute 6. GRADE: Grading of Recommendations Assessment, Development and Evaluation. P value < 0.05 was considered to be statistically significant