From: Signs of neuroinflammation outweigh neurodegeneration as predictors for early conversion to MS
 | Group 1 | Group 2 |  | CIS group |  | |||
---|---|---|---|---|---|---|---|---|
CIS N=22 | 1st attack MS N=20 | p-value | MS convertors N=9 | MS non-convertors N=13 | p-value | |||
Brain imaging | Â | Â | Â | Â | Â | Â | ||
 T2 MRI brain lesions | Typical | 11 (50%) | 20 (100%) | *0.003 | 7 (77.8%) | 4 (30.8%) | 0.08 | |
Atypical | 11 (50%) | 0 (0%) | 2 (22.2%) | 9 (69.2%) | ||||
 T1 black holes | ≥1 | 5 (22.7%) | 15 (75%) | *0.004 | 3 (33.3%) | 2 (15.4%) | 0.502 | |
 Total number of lesions | (mean ±SD) | 4.86±4.20 | 9.65±3.79 | *0.001 | 6.22±4.89 | 3.92±3.55 | 0.357 | |
Patients with MRI enhancing lesions | 5 (22.7%) | 15 (75%) | *0.001 | 3 (33.3%) | 2 (15.4%) | 0.841 | ||
 Substantia nigra echogenicity | Normal | 11 (55%) | 15 (75%) | 0.2 | 2 (25%) | 9 (75%) | 0.06 | |
Hypoechogenic | 9 (45%) | 5 (25%) | 6 (75%) | 3 (25%) | ||||
 Ventricular diameter | 3rd ventricle | Normal (%) | 14 (66.7%) | 17 (85%) | 0.277 | 5 (62.5%) | 9 (69.2%) | 1 |
Dilated (%) | 7 (33.3%) | 3 (15%) | 3 (37.5%) | 4 (30.8%) | ||||
Frontal horn | Median (cm) | 0.19 | 0.22 | 0.916 | 0.19 | 0.19 | 0.600 | |
Dilated (%) | 5 (25%) | 2 (10.5%) | 0.661 | 3 (37.5%) | 2 (16.7%) | 0.255 |