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Table 1 Clinical characteristics of all studied groups

From: Signs of neuroinflammation outweigh neurodegeneration as predictors for early conversion to MS

  Group 1 Group 2 P value CIS group P value
CIS
N=22
1st attack MS
N=20
MS convertors
N=9
MS non-convertors
N=13
Number (%) Number (%) Number (%) Number (%)
Age of onset (years) Mean ±SD 29.41 ± 6.94 28.50 ± 6.21 0.752 29.22 ± 5.19 29.54 ± 8.14 1.00
Sex Male 4 (18.2%) 4 (20.0%) 0.9 0 (0%) 4 (30.8%) 0.115
Female 18 (81.8%) 16 (80.0%) 9 (100%) 9 (69.2%)
Functional systems involved Multifocal presentation 7 (31.8%) 12 (60%) * 0.03 3 (33.3%) 4 (30.8%) 1
Monofocal presentation 15 (68.2%) 8 (40%) 0.067 6 (66.7%) 9 (69.2%) 1
Topography of mono-focal presentation Optic neuritis Yes 12 (80%) 5 (62.5%) 0.36 4 (66.7%) 8 (88.9%) 0.29
Typical 10 (83.3%) 4 (80%) 0.86 3 (75%) 8 (100%) 0.58
Atypical 2 (16.7%) 1 (20%) 1 (25%) 0 (0%)
Brain stem and cerebellar syndromes Yes 0 (0%) 0 (0%) -- 0 (0%) 0 (0%) --
Spinal cord syndrome Yes 1 (6.7%) 2 (25%) 0.21 1 (16.7%) 0 (0%) ---
Cerebral manifestations due to supratentorial lesions Yes 2 (13.3%) 1 (12.5%) 0.95 1 (16.7%) 1 (11.1%) 0.75
Sensory affection Yes 11 (50%) 17 (85%) 0.023 5 (55.6%) 6 (46.2%) 1
Total EDSS score median 2 3 0.111 2 2.5 0.27
MoCA test <26 10(45.5%) 3 (15%) 0.124 6 (66.7%) 4(30.8%) 0.328
  1. MS multiple sclerosis, CIS clinically isolated syndrome, EDSS using Expanded Disability Status Scale, MoCA Montreal Cognitive Assessment
  2. *p < 0.05 = significant