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Table 1 Clinical characteristics of all studied groups

From: Signs of neuroinflammation outweigh neurodegeneration as predictors for early conversion to MS

 

Group 1

Group 2

P value

CIS group

P value

CIS

N=22

1st attack MS

N=20

MS convertors

N=9

MS non-convertors

N=13

Number (%)

Number (%)

Number (%)

Number (%)

Age of onset (years)

Mean ±SD

29.41 ± 6.94

28.50 ± 6.21

0.752

29.22 ± 5.19

29.54 ± 8.14

1.00

Sex

Male

4 (18.2%)

4 (20.0%)

0.9

0 (0%)

4 (30.8%)

0.115

Female

18 (81.8%)

16 (80.0%)

9 (100%)

9 (69.2%)

Functional systems involved

Multifocal presentation

7 (31.8%)

12 (60%)

* 0.03

3 (33.3%)

4 (30.8%)

1

Monofocal presentation

15 (68.2%)

8 (40%)

0.067

6 (66.7%)

9 (69.2%)

1

Topography of mono-focal presentation

Optic neuritis

Yes

12 (80%)

5 (62.5%)

0.36

4 (66.7%)

8 (88.9%)

0.29

Typical

10 (83.3%)

4 (80%)

0.86

3 (75%)

8 (100%)

0.58

Atypical

2 (16.7%)

1 (20%)

1 (25%)

0 (0%)

Brain stem and cerebellar syndromes

Yes

0 (0%)

0 (0%)

--

0 (0%)

0 (0%)

--

Spinal cord syndrome

Yes

1 (6.7%)

2 (25%)

0.21

1 (16.7%)

0 (0%)

---

Cerebral manifestations due to supratentorial lesions

Yes

2 (13.3%)

1 (12.5%)

0.95

1 (16.7%)

1 (11.1%)

0.75

Sensory affection

Yes

11 (50%)

17 (85%)

0.023

5 (55.6%)

6 (46.2%)

1

Total EDSS score

median

2

3

0.111

2

2.5

0.27

MoCA test

<26

10(45.5%)

3 (15%)

0.124

6 (66.7%)

4(30.8%)

0.328

  1. MS multiple sclerosis, CIS clinically isolated syndrome, EDSS using Expanded Disability Status Scale, MoCA Montreal Cognitive Assessment
  2. *p < 0.05 = significant