From: Signs of neuroinflammation outweigh neurodegeneration as predictors for early conversion to MS
 | Group 1 | Group 2 | P value | CIS group | P value | |||
---|---|---|---|---|---|---|---|---|
CIS N=22 | 1st attack MS N=20 | MS convertors N=9 | MS non-convertors N=13 | |||||
Number (%) | Number (%) | Number (%) | Number (%) | |||||
Age of onset (years) | Mean ±SD | 29.41 ± 6.94 | 28.50 ± 6.21 | 0.752 | 29.22 ± 5.19 | 29.54 ± 8.14 | 1.00 | |
Sex | Male | 4 (18.2%) | 4 (20.0%) | 0.9 | 0 (0%) | 4 (30.8%) | 0.115 | |
Female | 18 (81.8%) | 16 (80.0%) | 9 (100%) | 9 (69.2%) | ||||
Functional systems involved | Multifocal presentation | 7 (31.8%) | 12 (60%) | * 0.03 | 3 (33.3%) | 4 (30.8%) | 1 | |
Monofocal presentation | 15 (68.2%) | 8 (40%) | 0.067 | 6 (66.7%) | 9 (69.2%) | 1 | ||
Topography of mono-focal presentation | Optic neuritis | Yes | 12 (80%) | 5 (62.5%) | 0.36 | 4 (66.7%) | 8 (88.9%) | 0.29 |
Typical | 10 (83.3%) | 4 (80%) | 0.86 | 3 (75%) | 8 (100%) | 0.58 | ||
Atypical | 2 (16.7%) | 1 (20%) | 1 (25%) | 0 (0%) | ||||
Brain stem and cerebellar syndromes | Yes | 0 (0%) | 0 (0%) | -- | 0 (0%) | 0 (0%) | -- | |
Spinal cord syndrome | Yes | 1 (6.7%) | 2 (25%) | 0.21 | 1 (16.7%) | 0 (0%) | --- | |
Cerebral manifestations due to supratentorial lesions | Yes | 2 (13.3%) | 1 (12.5%) | 0.95 | 1 (16.7%) | 1 (11.1%) | 0.75 | |
Sensory affection | Yes | 11 (50%) | 17 (85%) | 0.023 | 5 (55.6%) | 6 (46.2%) | 1 | |
Total EDSS score | median | 2 | 3 | 0.111 | 2 | 2.5 | 0.27 | |
MoCA test | <26 | 10(45.5%) | 3 (15%) | 0.124 | 6 (66.7%) | 4(30.8%) | 0.328 |