Table 5 Association between demographic, clinical, and MRI characteristics and cognitive dysfunction in MS and NMOSD patients
Characteristic | MS (FAB) | NMOSD (FAB) | MS (no. of cognitive domains involved) | NMOSD (no. of cognitive domains involved) | MS (no. of executive subdomains involved) | NMOSD (no. of executive subdomains involved) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
r | p | r | p | r | p | r | p | r | p | r | p | |
Age | − .315 | .048 | − .309 | .185 | .446 | .004 | .197 | .404 | .309 | .053 | .238 | .311 |
Gender (female) | NA | .339 | NA | .009 | NA | .068 | NA | .009 | NA | .086 | NA | .531 |
Formal education in years | .301 | .051 | .385 | .093 | − .358 | .023 | − .263 | .261 | − 0.632 | < .0001 | − .283 | .227 |
Disease duration | − .021 | .898 | .284 | .224 | .158 | .332 | − .029 | .902 | .219 | .175 | .044 | .854 |
No. of relapses | .146 | .368 | .233 | .323 | − .125 | .443 | − .060 | .802 | − .279 | .175 | − .114 | .633 |
EDSS | .101 | .534 | − .704 | .001 | − .097 | .550 | .514 | .020 | − .134 | .410 | .240 | .308 |
MRI lesion load | − .386 | .014 | − .040 | .867 | .268 | .094 | .232 | .325 | .292 | .068 | .176 | .457 |
OCB positivity | NA | .012 | NA | NA | NA | < .0001 | NA | NA | NA | < .0001 | NA | NA |