Table 1 Comparative risk homozygous haplotype regions among overall landscape and specific to autism
Sample type | Category | Risk haplotype homozygous regions overall landscape | Risk haplotype homozygous regions-autism specific | ||||||
|---|---|---|---|---|---|---|---|---|---|
Chromo somal location | Max score | rHH regions count | Genes identified number | Chromosomal loci | Max score* | rHH regions count | Associated genes identified | ||
Autism Trios using Affymetrix Mapping 250k Nsp SNP Array | A1 | 2,4,7,8, 11,12 | 4500-5700 | 12 | 29 | 8: 50280717-50921942 | 5714 | 6 | SNTG1-RELN |
11:49038697-49228613 | 4645 | FOLH1 | |||||||
11:48086151-48110043 | 4603 | PTPRJ-JAK2 | |||||||
12:88808147-89252667 | 5154 | KITLG | |||||||
12:88459309-88681867 | 4592 | CEP290, KITLG | |||||||
Autism Trios using Affymetrix Mapping 250k Sty SNP Array | A2 | 2,8,9,10 | 4000-5000 | 11 | 102 | 16:31716601-46710869 | 4827 | 6 | SLC6A10P,TP53TG3,TP53TG3B |
Autism cases Yoruba HapMap genotype as Controls using Affymetrix Mapping 250k Nsp SNP Array | B1 | 4,8,11 | 21000-24000 | 9 | 28 | 8:50280717-50808334 | 24275 | 3 | SNTG1-RELN |
11:49038697-49295867 | 21801 | FOLH1 | |||||||
11:48168664-48293931 | 21778 | PTPRJ-JAK2 | |||||||
Autism cases Yoruba HapMap genotype as Controls using Affymetrix Mapping 250k Sty SNP Array | B2 | 3,11,16 | 18268 | 6 | 145 | 3:51880614-52047421 | 18268 | 3 | ACY1, ABHD14A |