Outcomes and issues of 12 chordomas treated in a single center

Karampouga, Maria; Tsetsos, Fotis; Sakellariou, Pavlos; Baltas, Ioannis

doi:10.1186/s41983-021-00306-3

Table 3 Details on patient characteristics, treatment, and outcomes. Summary of all treated patients

From: Outcomes and issues of 12 chordomas treated in a single center

No.	Age, sex	Site	Tumor extension	DOS (m)	Extent of removal	Approach		Adjuvant management	Pre-op KPS	OS (m)	PFS (m)	Status
1.	32, M	CCJ	C2	12	1. NTR	1. Combined 2-staged transoral excision and posterior occipitocervical stabilization		Protons	90	12	12	NEP
2.	42, M	T12	Extraspinal (Enneking IB)	40	1. Incomplete 2. Incomplete	1. Combined 3-staged approach: posterior decompression and transpedicular instrumentation followed by left-sided transthoracic vertebral body replacement with a distractible device and right-sided thoracotomy for partial excision of the remnant tissue 2. Posterior decompression		SRS+ Imatinib	80	24	4	APD
3.	47, M	C4	Para-pharyngeal space (Enneking IB)	3	1. NTR 2. NTR 3. Incomplete 4. Incomplete	1. Anterior C-4 corpectomy with fusion 2. Anterior excision of recurrent soft tissue mass 3. 2-staged cervical laminectomy and anterior replacement of Ti-mesh with autogenous iliac bone graft 4. Posterior decompression		Photons+ Imatinib	90	76	24	APD
4.	49, M	T4,5	Extraspinal (Enneking IB) (WBB 2-5/A-C)	18	1. NTR^a 2. NTR^a 3. Incomplete^a 4. Incomplete	1. Resection through a posterior approach ^a 2. Pedicle screw fixation followed by lateral extracavitary vertebrectomy and expandable titanium cage placement^a 3. Posterior decompression^a 4. Posterior decompression		Photons + Rapamycin	90	50	12	DPD +DM
5.	22, M	SB	Middle fossa	7	1. NTR	1. Classic pterional approach		None	90	44	44	NEP
6.	65, M	SB	Sphenoid sinus	13	1. Biopsy	1. Transnasal transsphenoidal approach		Photons	40	3	0	DPD
7.	63, F	C4	Extraspinal (Enneking IB)	4	1. NTR 2. Incomplete	1. Anterior C-4 corpectomy, titanium mesh implantation and plating 2. Recurrent tumor excision via a front approach		Photons	70	46	16	DPD
8.	60, M	SB	Parasellar	12	1. Incomplete	1. Combined/2-staged pterional and transsphenoidal approach		None	70	26	6	DPD
9.	56, F	SB	Posterior fossa	6	1. Incomplete 2. Incomplete	1. Lateral suboccipital approach 2. Subtemporal approach		SRS	50	16	3	DPD
10.	24, M	SB	Sella turcica Ethmoid sinus	30	1. Incomplete 2. Incomplete	1. Pterional approach 2. Open door maxillotomy^b	VP-shunt	Photons	60	12	6	OpD
11.	69, M	SB	Supra-sellar	24	1. Biopsy	1. Transnasal transsphenoidal approach		NR	70	36^c	9	DPD
12.	46, M	T11 L4	Extraspinal (Enneking IB)	NR	1. T Incomplete C NTR	1. Anterior corpectomy and fixation 2. Combined 2-staged posterior instrumentation and anterior lumbar corpectomy with fusion		NR	80	NR	NR	NR

CCJ, craniocervical junction; WBB, Weinstein-Boriani-Biagini; DOS, duration of symptoms; m, months; NTR, near total resection; SRS, stereotactic radiosurgery; OS, overall survival; PFS, progression-free survival; NEP, no evidence of progression; APD, alive with progressive disease; DM, distant metastasis; DPD, dead of progressive disease; OpD, operative death; NR, not reported
^aSurgeries before admission
^bsurgeries in a foreign medical institution
^ccensored at last contact and believed to be dead of disease soon after

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