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Table 3 Details on patient characteristics, treatment, and outcomes. Summary of all treated patients

From: Outcomes and issues of 12 chordomas treated in a single center

No. Age, sex Site Tumor extension DOS
(m)
Extent of removal Approach Adjuvant management Pre-op KPS OS (m) PFS (m) Status
1. 32, M CCJ C2 12 1. NTR 1. Combined 2-staged transoral excision and posterior occipitocervical stabilization Protons 90 12 12 NEP
2. 42, M T12 Extraspinal (Enneking IB) 40 1. Incomplete
2. Incomplete
1. Combined 3-staged approach: posterior decompression and transpedicular instrumentation followed by left-sided transthoracic vertebral body replacement with a distractible device and right-sided thoracotomy for partial excision of the remnant tissue
2. Posterior decompression
SRS+ Imatinib 80 24 4 APD
3. 47, M C4 Para-pharyngeal space
(Enneking IB)
3 1. NTR
2. NTR
3. Incomplete
4. Incomplete
1. Anterior C-4 corpectomy with fusion
2. Anterior excision of recurrent soft tissue mass
3. 2-staged cervical laminectomy and anterior replacement of Ti-mesh with autogenous iliac bone graft
4. Posterior decompression
Photons+ Imatinib 90 76 24 APD
4. 49, M T4,5 Extraspinal
(Enneking IB)
(WBB 2-5/A-C)
18 1. NTRa
2. NTRa
3. Incompletea
4. Incomplete
1. Resection through a posterior approach a
2. Pedicle screw fixation followed by lateral extracavitary vertebrectomy and expandable titanium cage placementa
3. Posterior decompressiona
4. Posterior decompression
Photons + Rapamycin 90 50 12 DPD
+DM
5. 22, M SB Middle fossa 7 1. NTR 1. Classic pterional approach None 90 44 44 NEP
6. 65, M SB Sphenoid sinus 13 1. Biopsy 1. Transnasal transsphenoidal approach Photons 40 3 0 DPD
7. 63, F C4 Extraspinal
(Enneking IB)
4 1. NTR
2. Incomplete
1. Anterior C-4 corpectomy, titanium mesh implantation and plating
2. Recurrent tumor excision via a front approach
Photons 70 46 16 DPD
8. 60, M SB Parasellar 12 1. Incomplete 1. Combined/2-staged pterional and transsphenoidal approach None 70 26 6 DPD
9. 56, F SB Posterior fossa 6 1. Incomplete
2. Incomplete
1. Lateral suboccipital approach
2. Subtemporal approach
SRS 50 16 3 DPD
10. 24, M SB Sella turcica
Ethmoid sinus
30 1. Incomplete
2. Incomplete
1. Pterional approach
2. Open door maxillotomyb
VP-shunt Photons 60 12 6 OpD
11. 69, M SB Supra-sellar 24 1. Biopsy 1. Transnasal transsphenoidal approach NR 70 36c 9 DPD
12. 46, M T11
L4
Extraspinal
(Enneking IB)
NR 1. T Incomplete C NTR 1. Anterior corpectomy and fixation
2. Combined 2-staged posterior instrumentation and anterior lumbar corpectomy with fusion
NR 80 NR NR NR
  1. CCJ, craniocervical junction; WBB, Weinstein-Boriani-Biagini; DOS, duration of symptoms; m, months; NTR, near total resection; SRS, stereotactic radiosurgery; OS, overall survival; PFS, progression-free survival; NEP, no evidence of progression; APD, alive with progressive disease; DM, distant metastasis; DPD, dead of progressive disease; OpD, operative death; NR, not reported
  2. aSurgeries before admission
  3. bsurgeries in a foreign medical institution
  4. ccensored at last contact and believed to be dead of disease soon after