Validity of neuron-specific enolase as a prognostic tool in acute ischemic stroke in adults at Suez Canal University Hospital

Table 6 Agreement (sensitivity, specificity) for serum level of neuron-specific enolase (NSE) and clinical severity of stroke (NIHSS)predict mortality (n = 6)

NSE	AUC	p	95% C.I	Cutoff^a	Sensitivity	Specificity	PPV	NPV
NSE at presentation	0.836	0.010*	0.642–1.030	> 33.45	66.67	96.77	80.0	93.7
NSE at 48 h	0.855	0.007*	0.690–1.019	> 31.04	66.67	93.55	66.7	93.5
NIHSS at presentation	0.978	< 0.001*	0.938–1.019	> 19	100.0	90.32	66.7	100.0

AUC, area under a curve; p value, probability value; CI, confidence intervals; NPV, negative predictive value; PPV, positive predictive value; NSE, neuron-specific enolase; NIHSS, National Institutes of Health Stroke Scale
*Statistically significant at p ≤ 0.05
^aCutoff was chosen according to Youden index