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Table 1 Comparison of the demographic features, clinical findings, EEG results, and AED(s) used

From: Assessment of the response to antiepileptic drugs in epileptic patients with structural lesion(s) on neuroimaging

 

Total (n = 165)

Controlled (< 1 seizure per month), n = 40

Uncontrolled (≥ 1 seizure per month), n = 125

P value

Sex

Male

99 (60%)

25 (62.5%)

74 (59.2%)

0.711

Female

66 (40%)

15 (37.5%)

51 (40.8%)

Age

Range, mean ± SD

3–68, 29.9 ± 12.6

2–62, 34.7 ± 12.5

0.3–50, 28.4 ± 12.4

0.005*

Median

28 (20–37)

35 (27–40)

27 (19–36)

Age of onset

Mean ± SD

16.1 ± 13.6

22.7 ± 15.7

14 ± 12.1

0.001*

Median

13 (5–24)

22.5 (8–34.5)

11 (4–20)

Duration of epilepsy

Mean ± SD

13.9 ± 9.9

12 ± 9.5

14.5 ± 10

0.152

Median

13 (5.7–20.5)

11.5 (3–18)

13 (6–21)

Family history

Yes

22 (13.3%)

2 (9.1%)

20 (90.9%)

0.075

No

143 (86.7%)

38 (26.6%)

105 (73.4%)

History of status epilepticus

Yes

22 (13.3%)

8 (36.4%)

14 (63.6%)

0.154

No

143 (86.7%)

32 (22.4%)

111 (77.6%)

History of febrile seizures

Yes

12 (7.3%)

4 (33.3%)

8 (66.7%)

0.487

No

153 (92.7%)

36 (23.5%)

117 (76.5%)

Mentality

Normal

139 (84.2%)

36 (25.9%)

103 (74.1%)

0.251

Abnormal

26 (15.8%)

4 (15.4%)

22 (84.6%)

Type of seizure

Generalized

Motor

33 (20%)

9 (35%)

24 (65%)

0.413

Non-motor

33 (20%)

9 (35%)

24 (65%)

Focal

Motor

120 (72.7%)

30 (25%)

90 (75%)

0.679

Non-motor

8 (4.8%)

1 (12.5%)

7 (87.5%)

Aware

90 (54.5%)

20 (22.2%)

70 (77.8%)

0.417

Impaired awareness

38 (23%)

11 (28.9%)

27 (71.1%)

To BTC

99 (60%)

28 (28.3%)

71 (71.7%)

0.047*

Not to BTC

29 (17.6%)

3 (10.3%)

26 (89.7%)

EEG

Normal

53 (32.1%)

14 (25.9%)

40 (74.1%)

0.160

Abnormal

74 (44.9%)

11 (15.7%)

59 (84.3%)

No. of antiepileptic drugs

1

32 (19.4%)

20 (50%)

12 (9.6%)

< 0.001*

2

87 (52.7%)

17 (42.5%)

70 (56%)

0.137

3 or more

46 (27.9%)

3 (7.5%)

43 (34.4%)

0.001*

Type of antiepileptic

1st generation

57 (34.5%)

24 (60%)

33 (26.4%)

< 0.001*

2nd generation

12 (7.3%)

5 (12.5%)

7 (5.6%)

0.165

1st + 2nd

96 (58.2%)

11 (27.5%)

85 (68%)

< 0.001*

  1. SD standard deviation, EEG electroencephalography, BTC bilateral tonic-clonic
  2. *P value < 0.05 is significant, and P value < 0.01 is highly significant