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Table 3 Incidence of some abnormal movements in the literature

From: Cinnarizine- and flunarizine-associated movement disorder: a literature review

MDDrugReferenceYearNRNIncidenceStudied disease
PKNCNZMartí-Masso et al.198741040%Parkinson’s disease
PKNFNZMartinez-Lage1988114350.07%Migraine
TremorFNZCentozone et al.19901402.50%Migraine
BradykinesiaFNZMicheli et al.19902728.57%Tourette’s syndrome
TremorCNZWilder-Smith et al.19911147.10%Emesis
AKTCNZWilder-Smith et al.19911147.10%Emesis
PKNFNZHandforth et al.19951166.25%Epilepsy
EPSFNZBiary et al.199521711.76%Essential tremor
TremorFNZVecchio et al.199631225%Essential tremor
EPSFNZVerspeelt et al.1996368374.30%Migraine
EPSFNZVerspeelt et al.199677640.91%Vestibular vertigo
PKNFNZ/CNZLin et al.201628098302.90%Several
EPSFNZJhang et al.*2017--21.03%Several
EPSCNZJhang et al.*2017--10.30%Several
TremorFNZKarsan et al.201892004.50%Migraine
MicrographiaFNZKarsan et al.201822001%Migraine
PKNFNZLin et al.*2019--8.72%Migraine
  1. Abbreviations: AKT akathisia, CNZ cinnarizine, EPS extrapyramidal symptoms, FNZ flunarizine, N number of individuals in the study, NR number of reports with the movement disorder, PKN parkinsonism
  2. *Jhang et al. incidence rate (per 10,000 person-months); Lin et al. incidence rate (per 1000 person-years)