Table 2 General characteristics of the studies used in the systematic review
From: Olanzapine in the treatment of anorexia nervosa: a systematic review
Name of study | Type of study | Number of participants and age (year) | Therapy details | Efficiency |
|---|---|---|---|---|
Hansen L [17] | Case report | 1 (age: 49) | 10 mg/day olanzapine | Effective |
La Via et al. [18] | Case series | 2 (age: 15 and 27) | 5 mg/day olanzapine | Effective |
Jensen and Mejhede [19] | Case series | 3 (age: 30, 34, 50) | 5-10 mg/day olanzapine + psychotherapy | Effective |
Mehler et al. [20] | Case series | 5 (age: 12, 17) | Variable doses of olanzapine ± psychotherapy | Effective |
Powers et al. [21] | Case control study | 14 (age:14-56 with mean age of 26.8) | 10 mg/day olanzapine for 10 weeks + psychotherapy | Effective |
Ercan et al. [22] | Case report | 1 (age: 15) | 20 mg/day olanzapine | Effective |
Dennis et al. [23] | Case series | 5 (age: 12-18) | Variable doses of olanzapine ± psychotherapy | Effective |
Brambilla et al. [24] | Randomized placebo-controlled trial | 20 (mean age: 23 ± 4.8) | 2.5 mg/day for 2 months and 5 mg/day for 2 months | Ineffective |
Bissada et al. [25] | Randomized placebo-controlled trial | 34 (mean age: 29.67 ± 11.59) | Variable doses of olanzapine for 10-week period | Effective |
Brown University (17) [26] | Case control study | 13 (age non-specified) | 2.5 mg olanzapine for 6 weeks | Effective |
Leggero et al. [27] | Case control study | 13 (mean age: 13.7 ± 2.3) | Low dose olanzapine for 6 months + psychotherapy | Effective |
Capasso et al. [28] | Case report | 1 (age: 19) | 2.5 mg olanzapine for 1 month and 5 mg for 3 months | Effective |
Attia et al. [29] | Randomized, double blind, placebo-controlled trial | 23 (mean age: 27.7 ± 9.1) | 2.5-10 mg olanzapine for 8 weeks ± anti-depressants | Effective |
Kafantaris et al. [30] | Randomized, double blind, placebo-controlled trial | 15 (mean age: 17.1 ranging between 12 and 21) | Low dose olanzapine for 10 weeks | Not effective |
Pirkalani and Anorexia [31] | Case control study | 27 (age non-specified) | 2.5 mg olanzapine for 6 weeks + citalopram + vitamin B6 | Effective |
Bangratz et al. [32] | Case control study | 16 (age: 11-17) | 5-10 mg olanzapine for 5 weeks | Effective |
Duvvuri et al. [33] | Case report | 1 (age: 12) | 2.5 mg olanzapine for 36 weeks | Effective |
Haruta et al. [34] | Case report | 1 (age: 36) | 20 mg day paroxetine +2.5 mg day olanzapine + psychotherapy | Not effective in weight restoration, hypoglycemia develops |
Kesic et al. [35] | Case control study | 24 (age: 14-20) | 2.5-7.5 mg olanzapine for 3-42 weeks ± psychotherapy ± anti-depressants | Effective |
Alwazeer et al. [36] | Case report | 1 (age: 16) | 2.5-7.5 mg olanzapine for 4 weeks | Effective in weight restoration, heart block develops |
Ayyıldız et al. [37] | Case report | 1 (age: 17) | 5 mg day olanzapine + psychotherapy | Efficiency unknown, neuroleptic malignant syndrome develops on day 2 |
Himmerich et al. [38] | Case control study | 12 (age: 18-60) | 8 weeks of olanzapine | Effective |
Spettigue et al. [39] | Case control study | 32 (age: 11-17) | Open label trial with various dosage and duration | Effective |
Attia et al. [40] | Randomized double-blind placebo-controlled trial | 152 (age: 18-65) | 2.5-10 mg olanzapine for 16 weeks | Efficient in terms of weight restoration |