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Table 3 Comparison between pre- and post-levetiracetam (group II) treatment regarding sex hormone assay and sperm parameters

From: Effect of valproate versus levetiracetam monotherapy on reproductive functions in newly diagnosed epileptic males

Variable

Levetiracetam (group II)

P value

Pre-treatment

Post-treatment

Sex hormones assay

• Luteinizing hormone (LH)

4.7 ± 2.0

3.7 ± 1.9

0.07

• Follicle-stimulating hormones (FSH)

6.4 ± 3.16

5.1 ± 3.3

0.11

• Prolactin (PRL)

8.65 ± 4.2

8.0 ± 3.6

0.12

• Testosterone (T)

5.7 ± 1.6

5.0 ± 1.97

0.07

• Estradiol (E2)

25.1 ± 11.7

24.6 ± 11.5

0.6

Sperm parameters

• Concentration

29.1 ± 12.6

23.2 ± 10.3

0.01*

• Total count

45.6 ± 9.1

38.8 ± 8.3

0.01*

• Total motility

57.96 ± 10.9

48.1 ± 12.3

0.001**

• Normal morphology

6.3 ± 1.8

5.1 ± 1.5

0.01*

  1. Data are represented in mean ± SD
  2. *Significant
  3. **Highly significant