Table 2 Comparison between pre- and post-valproate (group I) treatment regarding sex hormone assay and sperm parameters
Variable | Valproate (group I) | P value | |
|---|---|---|---|
Pre-treatment | Post-treatment | ||
Sex hormones assay | |||
• Luteinizing hormone (LH) | 4.86 ± 1.8 | 3.4 ± 1.37 | 0.01* |
• Follicle-stimulating hormones (FSH) | 6.0 ± 2.6 | 4.6 ± 2.8 | 0.01* |
• Prolactin (PRL) | 8.5 ± 4.0 | 14.7 ± 8.4 | < 0.001** |
• Testosterone (T) | 5.8 ± 2.0 | 5.4 ± 1.8 | 0.1 |
• Estradiol (E2) | 25.4 ± 11.3 | 24.6 ± 10.9 | 0.9 |
Sperm parameters: | |||
• Concentration | 29.9 ± 12.8 | 25 ± 12.1 | 0.01* |
• Total count | 45.6 ± 9.0 | 37.6 ± 9.1 | 0.01* |
• Total motility | 58.2 ± 10.1 | 45.8 ± 14.0 | 0.001** |
• Normal morphology | 3.4 ± 1.4 | 2.88 ± 1.05 | 0.029* |