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Table 1 2010 CDC Criteria for sporadic CJD

From: Probable Creutzfeldt-Jakob disease—a case report at Suez Canal University Hospital, Egypt

Definite

Detection of protease-resistant prion protein or scrapie-associated fibrils by neuropathology, immunochemical technique, and/or Western blot.

Probable

No findings indicating alternative diagnoses AND progressive dementia with at least 2 of (i)–(iv) AND at least one of (a)–(c).

Possible

No findings indicating alternative diagnoses AND progressive dementia with duration of less than 2 years AND with at least 2 of (i)–(iv) AND at least one of (a)–(c).

 (i) Myoclonus

 (ii) Visual or cerebellar problems

 (iii) Pyramidal or extrapyramidal features

 (iv) Akinetic mutism

  (a) Periodic sharp wave complexes on electroencephalography

  (b) Positive 14-3-3 protein in the cerebrospinal fluid with a disease duration of less than 2 years

  (c) High signal abnormalities in the caudate nucleus and/or putamen on diffusion-weighted imaging (DWI) or fluid-attenuated inversion recovery (FLAIR) MRI