Polysomnography, brain volumetry, and mismatch negativity as early biomarkers of amnestic mild cognitive impairment progression

Bahnasy, Wafik Said; El-Heneedy, Yasser Abo Elfotoh; Ragab, Osama Abd Allah; Badr, Marwa Yassin; Seleem, Mohammad Abdel-Hakeem; Amer, Reham Abdel Rahman; El-Shafey, Rasha Ahmed; Kotait, Mona Ahmed

doi:10.1186/s41983-018-0022-2

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Table 1 Comparison between progressive amnestic MCI (group I), stationary amnestic MCI (group II), and healthy control (group III) regarding polysomnographic, hippocampus/entorhinal cortex MRI volumetry, and mismatch negativity

From: Polysomnography, brain volumetry, and mismatch negativity as early biomarkers of amnestic mild cognitive impairment progression

	Group I	Group II	Group III	ANOVA
	Mean ± SD	Mean ± SD	Mean ± SD	f value	p value
Polysomnographic parameters
Total sleep time (min)	408 ± 31.9	404.8 ± 43.2	426.4 ± 41.1	1.37	0.264
Sleep latency (min)	14.63 ± 3.21	11.4 ± 2.9	12.17 ± 3.11	0.082	0.54
WASO (min)	59.43 ± 9.3	32.71 ± 7.03	32.02 ± 7.14	44.18	0.0001*
Sleep efficiency (%)	76.3 ± 3.55	82.56 ± 5.03	82.45 ± 3.98	6.70	0.003*
REM latency (min)	121.8 ± 12.1	80.56 ± 9.94	81.2 ± 7.66	51.83	0.0001*
REM % TST	9.82 ± 3.57	21.5 ± 3.51	22.21 ± 3.41	79.40	0.0001*
RSWA index	14.9 ± 4.8	13.41 ± 5.14	5.93 ± 2.10	9.74	0.0001*
N1% TST	10.46 ± 2.02	7.27 ± 1.47	7.07 ± 1.56	14.28	0.0001*
N2% TST	38.08 ± 2.75	40.64 ± 4.14	41.87 ± 3.57	2.61	0.084
N3% TST	35.85 ± 3.34	23.14 ± 4.99	20.24 ± 3.99	33.42	0.0001*
AHI (/h)	7.05 ± 4.5	12.08 ± 5.8	7.25 ± 2.34	10.68	0.0001*
Arousal index (/h)	11.18 ± 4.27	20.21 ± 7.95	8.22 ± 1.96	18.61	0.0001*
SSTI (/h)	13.87 ± 4.48	19.06 ± 4.68	11.28 ± 2.64	9.61	0.0001*
PLMs index (/h)	14.25 ± 6.79	13.66 ± 4.24	15.85 ± 3.63	1.12	0.334
Snore index (/h)	17.08 ± 5.77	26.86 ± 8.25	14.62 ± 3.13	18.03	0.0001*
MRI volumetry
Right hippocampus (cm³)	1.28 ± 0.13	2.02 ± 0.28	2.05 ± 0.28	21.41	0.0001*
Left hippocampus (cm³)	1.27 ± 0.12	2.03 ± 0.29	2.07 ± 0.31	21.33	0.0001*
Right entorhinal cortex (cm³)	1.26 ± 0.13	1.85 ± 0.12	1.85 ± 0.12	64.31	0.0001*
Left entorhinal cortex (cm³)	1.27 ± 0.11	1.86 ± 0.11	1.85 ± 0.12	72.11	0.0001*
Auditory mismatch negativity
Right MMN latency (ms)	252.2 ± 20.2	190.4 ± 18.7	194.5 ± 15.8	37.46	0.0001*
Left MMN latency (ms)	251.2 ± 21.2	191.7 ± 19.4	195.3 ± 15.2	32.82	0.0001*
Right MMN amplitude (μV)	2.02 ± 0.66	3.89 ± 0.88	3.65 ± 0.88	15.13	0.0001*
Left MMN amplitude (μV)	2.03 ± 0.65	3.89 ± 0.88	3.73 ± 1.04	13.58	0.0001*

*Significant; AHI apnea hypopnea index, MMN mismatch negativity, N1, N2, N3 non-rapid eye movement stages 1, 2, 3, PLMs periodic limb movements, REM rapid eye movement, RSWA REM sleep without atonia, SSTI sleep stage transition index, TST total sleep time, WASO wake after sleep onset

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