STAT4 gene polymorphism in two major autoimmune diseases (multiple sclerosis and juvenile onset systemic lupus erythematosus) and its relation to disease severity

Table 5 Comparing laboratory findings in patients with JO-SLE according to STAT4 polymorphic variants (CC, GC, and GG)

Variable	CC (n = 7)	GC (n = 17)	GG (n = 16)	P value
24-h protein in urine(mg/24 h)	1346 ± 616*	1189 ± 215*	698 ± 807	0.02
C3 level (mg/dl)	31.34 ± 11.8*⁺	51.32 ± 17.55	58.1 ± 14.5	0.01
C4 level (mg/dl)	6.61 ± 2.08*⁺	13.3 ± 2.88	16.9 ± 3.95	0.03
Anti-ds-DNA	6(86%)*	9(53%)	8(50%)	0.01
ANA	7(100%)*	17(100%)*	14(88%)	0.02
Ant SS-A	2(29%)	5(29%)	7(44%)	0.3
Anti SS-B	0	0	3(19%)	0.5
Anti Sm	3(43%)*⁺	2(12%)	3(19%)	0.04
Anti RNP	1(14%)	3(18%)	3(19%)	0.11
Anti Scl 70	1(14%)	2(12%)	2(13%)	0.8
Anti Jo-1	1(14%)	0	0	0.9

Chi square and post hoc chi-square for qualitative and ANOVA for quantitative data. Quantitative parametric data are represented in mean (±SD) and numerical data are represented in numbers and percentage
*Significant comparing either the first or second column versus third column
⁺Significant comparing the first column versus second column